January 17, 2020
SHARE special Guest Speaker Seminar
SHARE’s special Guest Speaker Seminar by Prof Ze’ev Paroush from the Hebrew University of Jerusalem, was held on the 17 Dec 2019, at SHARE.
Prof Ze’ev Paroush focuses on Developmental Biology and Cancer Research.
Prof Ze’ev Paroush title: “A novel role for the Groucho co-repressor in cell cycle regulation”.
Abstract: “ Excessive cell proliferation often drives tumour formation and aggressiveness, and is one of the major hallmarks of cancer. Accordingly, great efforts are dedicated towards revealing novel tiers of regulation and therapeutic approaches that would suppress uncontrolled cell divisions. In my talk, I will present a novel regulatory function for the Drosophila Groucho corepressor in the cell cycle. In particular, I will show that Groucho mediates repression of specific target genes at S-phase, and that subsequent down-regulation of this activity is crucial for the S-to-G2-phase transition. Thus, our findings reveal a previously unappreciated level of transcriptional control that is essential for normal cell cycle progression’’.